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Updated: Aug 14, 2026

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling
Published on: August 3, 2018
Lipids in endothelial-to-mesenchymal transition
Christina K Tripsas1,2, Abigail Y Tsai3, Jeffrey J Hsu2,4,5,6
1Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of California, Los Angeles David Geffen School of Medicine.
Purpose Of Review:
Endothelial-to-mesenchymal transition (EndMT) has been implicated in the development of cardiovascular disease, including atherosclerosis. EndMT is a complex continuum with multiple involved pathways, each with different pathophysiologic implications depending on the driving regulators.
Recent Findings:
In this brief review, we will focus on the latest studies that have helped elucidate the role of lipids and related factors in the initiation of EndMT in the setting of atherosclerosis, with particular attention to atherosclerotic plaque stability and sex specific differences of disease.
Summary:
We explore potential therapeutic strategies, including the impact that lipid modulation has on EndMT and the effects of EndMT-specific approaches on lipid deposition. Overall, this will inform future areas of research on EndMT modulation.
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