Related Experiment Video

Updated: Aug 14, 2026

Adaptation of Semiautomated Circulating Tumor Cell (CTC) Assays for Clinical and Preclinical Research Applications
14:14

Adaptation of Semiautomated Circulating Tumor Cell (CTC) Assays for Clinical and Preclinical Research Applications

Published on: February 28, 2014

Castleman disease: application of modern classification in a Canadian center

Rebecca MacLeod1, Mark Trinder2, Liliana Wolak3

  • 1Department of Medicine, University of British Columbia, Vancouver, Canada.

Expert Review of Clinical Immunology
|August 13, 2026
PubMed

Insights

Castleman disease (CD) presents heterogeneously, posing diagnostic challenges. This Canadian study found varied subtypes and treatment responses, emphasizing subtype awareness for better patient outcomes.

Area of Science:

  • Hematology
  • Rare Diseases
  • Oncology

Background:

  • Castleman disease (CD) is a rare, heterogeneous lymphoproliferative disorder.
  • Recent classification changes highlight diagnostic and management complexities.
  • Understanding CD subtypes is crucial for effective patient care.

Purpose of the Study:

  • To describe the diagnostic and treatment experiences with Castleman disease at a Canadian center.
  • To analyze the presentation, natural history, and treatment response across CD subtypes.

Main Methods:

  • Retrospective cohort study of 23 biopsy-confirmed Castleman disease patients.
  • Data collected from patients evaluated and treated at the University of British Columbia (2016-2025).

Main Results:

  • The cohort included unicentric CD (UCD), OligoCD, and multicentric CD (MCD) subtypes.
  • Idiopathic MCD (iMCD) subtypes included iMCD-TAFRO, iMCD-IPL, and iMCD-NOS.
  • Diagnosis times varied significantly by subtype, with iMCD-TAFRO being the fastest (1 month) and iMCD-IPL the slowest (82 months).
  • Targeted therapies (Siltuximab, Tocilizumab) showed high response rates (86-100%) across iMCD subtypes.

Conclusions:

  • Castleman disease exhibits diverse clinical presentations, natural history, and treatment responses.
  • Awareness of specific CD subtypes is essential for optimizing diagnosis and management.
  • Limitations include the retrospective design and small sample size, necessitating further research.
Abstract

Keywords:
AutoinflammationCastleman diseaseIgG4cytokine stormidiopathic plasmacytic lymphadenopathy

More Related Videos

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation10:33

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation

Published on: September 4, 2017

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Related Concept Videos

Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Diagnostic and Statistical Manual of Mental Disorders (DSM)01:27

Diagnostic and Statistical Manual of Mental Disorders (DSM)

The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...