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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Isolated Major Organ Involvement as the Initial Presentation of Systemic Lupus Erythematosus: A Diagnostic Challenge

Shweta Suryakant Khopde¹, Ashish Mohan Vidhate²

¹Department of General Medicine, Dr. D. Y. Patil Hospital and Research Centre, Pimpri, Pune, Maharashtra, India.

Annals of African Medicine

|August 13, 2026

Abstract

Background:

Systemic lupus erythematosus (SLE) typically presents with multisystem involvement; however, some patients present with isolated major organ disease, leading to diagnostic delay.

Objectives:

The objective of this study was to evaluate the frequency, clinical characteristics, and immunological profile of SLE patients presenting with isolated major organ involvement at disease onset.

Materials And Methods:

Adult patients fulfilling the Systemic Lupus International Collaborating Clinics 2012 criteria were evaluated. Patients presenting with isolated renal, neuropsychiatric, or cardiopulmonary involvement without classical features were identified.

Results:

Out of 45 SLE patients, 18 (40%) presented with isolated major organ involvement. Renal involvement was the most common isolated presentation. All patients showed antinuclear antibody positivity and hypocomplementemia.

Conclusion:

Isolated major organ involvement is a common and diagnostically challenging initial presentation of SLE.

Keywords:

Glomerulonephritis Lupus érythémateux systémique glomérulonéphrite lupus nephritis lupus neuropsychiatrique neuropsychiatric systemic lupus erythematosus néphrite lupique systemic lupus erythematosus

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