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AgPS3-Based Electrical Synapses with Tunable Multilevel Conductance for Noise-Robust Image Classification
Zongjie Zhan1, Hao Sun1, Yumo Li1
1College of Physics and Electronic Engineering, Northwest Normal University, Lanzhou, 730070, China.
The Journal of Physical Chemistry Letters
|August 13, 2026
Summary
Layered silver phosphorus trisulfide (AgPS3) enables artificial synaptic devices with tunable conductance for brain-inspired computing. This material enhances noise robustness in medical image classification using convolutional neural networks (CNNs).
Area of Science:
- Materials Science
- Neuroscience
- Computer Engineering
Background:
- Neuromorphic computing requires advanced artificial synaptic electronics for brain-inspired systems.
- Memristive devices with controllable conductance are crucial for neuromorphic applications.
- Novel functional materials are needed to achieve high-performance synaptic devices.
Purpose of the Study:
- To introduce layered silver phosphorus trisulfide (AgPS3) as a novel material for artificial synaptic devices.
- To investigate the neuromorphic application potential of AgPS3-based synaptic devices.
- To evaluate the performance of AgPS3 synapses in image processing tasks.
Main Methods:
- Fabrication of synaptic devices using layered AgPS3.
- Characterization of device conductance modulation under various electrical stimulation protocols.
- Design and implementation of a AgPS3 synapse-based Gaussian front-end for medical image preprocessing.
- Performance evaluation using BloodMNIST dataset and convolutional neural networks (CNNs).
Main Results:
- AgPS3 devices exhibit arbitrarily tunable multilevel conductance states.
- The devices successfully emulate biological synaptic functions, including stimulus-dependent weight update, memory transition, and frequency-selective signal processing.
- A AgPS3 synapse-based Gaussian front-end significantly enhances noise robustness in BloodMNIST classification via CNNs.
Conclusions:
- Layered AgPS3 is a promising candidate material for developing artificial synapses.
- AgPS3-based synaptic devices offer great prospects for edge-intelligent sensing and neuromorphic computing.
- The material shows potential for hardware-efficient image processing applications.

