Related Experiment Video
Updated: Aug 14, 2026

Production and Targeting of Monovalent Quantum Dots
Published on: October 23, 2014
Harnessing the quinoline core for targeted cancer therapy
Cong-Jun Liu1, Wei-Wen Huang1, Jun-Jie Wang2
1Innovative Practice Platform for Research-Oriented Teaching of Natural Product Resources Development and Application, Engineering Research Center for Bio-Based Medical Polymers of Henan Province, School of Food and Health Engineering, Zhengzhou University of Technology, Zhengzhou, China.
None:
The quinoline nucleus is a privileged scaffold valued for its structural plasticity and synthetic accessibility. This review systematically summarizes advances in quinoline derivatives for targeted cancer therapy from 2017 to 2026, organized by major molecular target families - including kinases, metabolic enzymes, epigenetic regulators, drug transporters, and others - with emphasis on rational design, key structure-activity relationships (SARs), and antitumor efficacy. Despite progress, challenges such as isoform selectivity, suboptimal pharmacokinetics, and drug resistance persist; future efforts should focus on dual-targeting and prodrug strategies to overcome these limitations. This review aims to provide medicinal chemistry insights for the design of next-generation quinoline-based anticancer agents with improved selectivity, pharmacokinetic properties, and ability to overcome drug resistance.
Related Concept Videos
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Treatment Resistant Cancers