Fibroblast Growth Factor 21 and Its Relationship with Central Precocious Puberty in Girls

Area of Science:

• Pediatric Endocrinology
• Metabolic Regulation
• Reproductive Health

Background:

• Obesity and insulin resistance are linked to central precocious puberty (CPP) in girls.
• Fibroblast growth factor 21 (FGF21) is associated with metabolic health and reproductive development.
• FGF21's role in CPP requires further investigation.

Purpose of the Study:

• To investigate serum FGF21 levels in girls with CPP.
• To explore the relationship between FGF21, β-Klotho, and CPP.

Main Methods:

• A case-control study included 106 girls (55 CPP, 51 controls) aged 6-10 years.
• Collected data: anthropometrics, hormone profiles, IGF1, bone age, ovarian/uterine development, FGF21, and β-Klotho.
• Statistical analysis compared groups and assessed correlations.

Main Results:

• Girls with CPP had significantly lower serum FGF21 and β-Klotho levels compared to controls.
• FGF21 and β-Klotho showed a negative correlation with CPP.
• ROC analysis indicated diagnostic potential for FGF21 (AUC=0.833) and β-Klotho (AUC=0.770).

Conclusions:

• Serum FGF21 and β-Klotho levels are significantly lower in girls with CPP.
• These findings suggest FGF21 may play a role in regulating puberty onset.
• Further research is needed to elucidate the molecular mechanisms involved.