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Conventional adherence assessment methods are low-sensitivity diagnostic tests in people with type 2 diabetes: The
Hanad Osman1,2,3, Sian Jenkins4, Prashanth Patel1,5,6
1Division of Cardiovascular Sciences, College of Life Sciences, University of Leicester, Leicester, UK.
Summary
Chemical adherence testing (CAT) is a more sensitive diagnostic tool for non-adherence in type 2 diabetes patients compared to conventional methods like MPR and HBMAS. CAT significantly correlates with HbA1c and blood pressure, unlike other methods.
Area of Science:
- Endocrinology
- Clinical Pharmacy
- Health Outcomes Research
Background:
- Medication adherence is crucial for managing type 2 diabetes (T2D).
- Conventional adherence assessment methods (e.g., surveys, MPR) have limitations in accuracy.
- Objective chemical adherence testing (CAT) offers a more precise measure of medication intake.
Purpose of the Study:
- To compare the performance of conventional adherence assessment methods with CAT in T2D patients.
- To evaluate the association of adherence measures with glycemic control (HbA1c) and blood pressure (BP).
Main Methods:
- Prospective cohort study involving 90 T2D participants in primary care.
- Assessment using CAT, medication possession ratio (MPR), and Hill-Bone Medication Adherence Scale (HBMAS).
- Analysis of associations with HbA1c and BP, and within-person diagnostic performance.
Main Results:
- CAT-defined non-adherence was significantly associated with higher HbA1c.
- CAT and MPR showed significant associations with diastolic BP.
- MPR and HBMAS exhibited low sensitivity and specificity compared to CAT in within-person analysis.
Conclusions:
- Conventional adherence assessment methods demonstrate low diagnostic sensitivity.
- CAT provides an improved diagnostic capability for identifying non-adherence in T2D management.
- Objective testing is recommended for accurate adherence assessment in T2D care.
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