Intermolecular network reorganization induced by hydroxyethyl cellulose enables structurally stable niacinamide-based...

Area of Science:

• Cosmetic Science
• Polymer Science
• Materials Science

Background:

• Developing stable and effective skin-brightening formulations is crucial in cosmetic science.
• Niacinamide is a key active ingredient for skin benefits, but its incorporation requires careful formulation for stability and efficacy.
• Functional polymers can enhance the physicochemical properties and performance of cosmetic emulsions.

Purpose of the Study:

• To develop a structurally stable skin-brightening moisturizing cream using hydroxyethyl cellulose (HEC) as a functional polymer.
• To evaluate the impact of HEC on the physicochemical properties, stability, and skin hydration performance of the formulation.
• To understand the mechanism by which HEC influences the cream's structure and performance.

Main Methods:

• Formulation development incorporating niacinamide and hydroxyethyl cellulose (HEC).
• Physicochemical and performance evaluation using bioelectrical impedance analysis (BIA), Fourier-transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM).
• Assessment of structural integrity under thermal and simulated sunlight exposure.

Main Results:

• HEC incorporation significantly improved skin hydration and provided moderate enhancement in thermal stability.
• FT-IR analysis indicated a reorganized polymer network within the cream matrix due to HEC.
• SEM confirmed improved morphological integrity, and TGA showed increased decomposition temperature, suggesting enhanced thermal resistance.
• HEC formed an entangled polymer network, stabilizing the emulsion and reducing moisture loss.

Conclusions:

• Hydroxyethyl cellulose (HEC) is an effective functional polymer for developing stable and hydrating skin-brightening moisturizing creams.
• HEC enhances structural coherence, emulsion stability, and thermal resistance through physical entanglement and intermolecular interactions.
• The developed formulation demonstrates improved performance in skin hydration and stability, making it a promising cosmetic product.