Related Experiment Video
Updated: Aug 15, 2026

Real-time Measurement of Epithelial Barrier Permeability in Human Intestinal Organoids
Published on: December 18, 2017
Smart-delivery systems for intestinal mucosal homeostasis: From barrier penetration to precision regulation
Minghui Shi1, Xiang Li1, Jiale Li1
1School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; Jiangsu Provincial TCM Engineering Technology Research Center of High Efficient Drug Delivery System, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Abstract:
As an important barrier tissue, the intestinal mucosa is responsible for regulating immunity, absorbing nutrients, and maintaining microbial homeostasis. Structural damage or functional impairment of the mucosa not only leads to a series of mucosa-related diseases but also may cause pathological changes in extramucosal organs. Given the central role of mucosal dysfunction in the onset and progression of various diseases, effectively regulating mucosal function and improving drug delivery efficiency are critical for improving clinical outcomes in gastroenterology. This article systematically reviews the structural characteristics and main functions of the intestinal mucosa, and analyzes the manifestations and underlying mechanisms of mucosal dysfunction. Based on this, we summarize recent advances in barrier enhancement, precise tissue and cell-level targeting, and microenvironment-responsive delivery strategies, and further elaborate on the latest progress in bio-inspired nanosystems for the treatment of gastrointestinal diseases. Finally, this article discusses the clinical trial progress, current challenges, and future development prospects of artificial intelligence optimization technology in the regulation of intestinal mucosa and drug delivery, aiming to provide theoretical basis and research references for in-depth studies on the regulation of intestinal mucosa function and the clinical application of related delivery systems.
Related Concept Videos
Renewal of Intestinal Stem Cells
Mucosal Barrier of the Stomach
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Absorption of Nutrients
Enterocytes, which are specialized polar epithelial cells, line the mucosa of the small intestinal walls. These cells...
Oral Drug Delivery Systems: Delayed-Release Systems
Transcellular Transport of Solutes