The skin-wrinkling test: principles and clinical applications

Area of Science:

• Neurology
• Dermatology
• Autonomic Nervous System Function

Background:

• Cutaneous wrinkling on palms is a normal, reversible phenomenon.
• Wrinkling is influenced by vasoconstriction and vasomotor function.
• Absence or reduction of wrinkling suggests disorders of sympathetic nerves.

Purpose of the Study:

• To review the principles and pathophysiology of the skin-wrinkling test.
• To explore its clinical indications for evaluating the autonomic nervous system.
• To highlight its utility as a screening tool for small-fiber neuropathy.

Main Methods:

• Assessment via the skin-wrinkling test after water immersion.
• Evaluation of vasoconstriction and vasomotor function.
• Review of existing literature on the test's application.

Main Results:

• The test assesses the sympathetic nervous system's role in palm wrinkling.
• Reduced wrinkling correlates with sympathetic nerve dysfunction.
• The test is a potential screening tool for small-fiber neuropathy.

Conclusions:

• The skin-wrinkling test is a rapid, inexpensive, and accessible method.
• It serves as a valuable tool when biopsy is not feasible.
• It aids in evaluating the sympathetic component of autonomic dysfunction.