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3D-Printable and Bioelectronic-Compatible Graphene-Reinforced PLA Nanocomposites Rejuvenate Aged Bone Regeneration
Mengjia Wang1, Yangheng Zhang1, Haiyang Pan2
1Department of Periodontology, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China.
Advanced Healthcare Materials
|August 14, 2026
Summary
Graphene-polylactic acid (G-PLA) nanocomposites accelerate bone healing by reprogramming cellular metabolism and enhancing vascularization, effectively counteracting age-related decline in healing capacity.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- Age-related factors like metabolic dysregulation, inflammation, and poor vascularization impair bone healing.
- Graphene-polylactic acid (G-PLA) nanocomposites show promise for bioelectronic encapsulation and guided bone regeneration.
Purpose of the Study:
- To investigate G-PLA nanocomposites as a bio-instructive interface for guided bone regeneration.
- To evaluate the efficacy of G-PLA in mitigating age-related declines in bone healing capacity.
Main Methods:
- Fabrication of G-PLA nanocomposites via in situ graphite exfoliation.
- Assessment of G-PLA in rat cranial defects using micro-CT, histology, and immunohistochemistry.
- Proteomic profiling and in vitro studies on endothelial cells, mesenchymal stem cells, and macrophages.
Main Results:
- G-PLA significantly accelerated bone regeneration in rat cranial defects.
- G-PLA effectively counteracted age-dependent decreases in healing capacity.
- G-PLA promoted glycolytic reprogramming, enhanced angiogenesis, and suppressed inflammation and senescence markers.
Conclusions:
- G-PLA nanocomposites act as a bio-instructive interface, revitalizing vascular-bone coupling.
- G-PLA offers a versatile framework for next-generation implantable hybrid systems for bone regeneration.
