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Updated: Aug 15, 2026
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Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
The association between prediabetes and obstructive sleep apnea syndrome: a meta-analysis
Lili Miao1, Quanming An2, Shaojin Wang1
1Department of Pulmonary and Critical Care Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.
Frontiers in Endocrinology
|August 14, 2026
Summary
Individuals with prediabetes have a significantly higher prevalence of obstructive sleep apnea syndrome (OSAS). This highlights the link between early glucose issues and sleep-disordered breathing, suggesting OSAS screening for prediabetes patients.
Area of Science:
- Metabolic dysfunction and sleep disorders research.
- Public health and epidemiology of chronic diseases.
Background:
- Obstructive sleep apnea syndrome (OSAS) is increasingly recognized for its association with metabolic dysfunction.
- The specific link between prediabetes and OSAS requires further clarification.
Purpose of the Study:
- To systematically evaluate the relationship between prediabetes and the prevalence of OSAS in adults through a meta-analysis.
Main Methods:
- A systematic search of PubMed, Embase, and Web of Science was conducted for observational studies.
- Studies focused on the association between prediabetes and objectively diagnosed OSAS.
- Odds ratios (ORs) were pooled using random-effects models to account for heterogeneity.
Main Results:
- Eight cross-sectional studies with 18,040 participants were included; 35.1% had prediabetes.
- Prediabetes was significantly associated with a higher prevalence of OSAS (OR = 2.78, 95% CI 1.99-3.87).
- Consistent associations were found across diverse populations and diagnostic methods, with stronger links in younger individuals and composite prediabetes criteria.
Conclusions:
- Prediabetes is significantly linked to a higher prevalence of OSAS in adults.
- Findings underscore the common co-occurrence of early glucose dysregulation and sleep-disordered breathing.
- OSAS screening is recommended for individuals diagnosed with prediabetes.
Related Concept Videos
01:21Sleep Apnea
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
01:13Insufficient Sleep and Sleep Deprivation
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
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01:24Sleep-Wake Cycles
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
01:17Other Pulmonary Disorders
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.