Dermal regeneration in full-thickness wounds: Clinical outcomes with novosorb^Ⓡ biodegradable temporising matrix

Complex full-thickness skin defects remain challenging to reconstruct due to the loss of regenerative dermal structures. Dermal regeneration templates such as the NovoSorb^Ⓡ Biodegradable Temporising Matrix (BTM) have been introduced to facilitate dermal regeneration prior to definitive skin grafting. We hereby describe the outcome following its use in the context of wound treatment. A retrospective analysis was conducted including all patients treated with BTM at a single plastic surgery center between March 2020 and February 2026. Demographic, clinical, microbiological, and surgical data were extracted from electronic health records. Outcomes of interest included BTM infection, BTM loss prior to skin grafting and skin graft take. Univariate and multivariable analyses were performed to identify factors associated with BTM loss. A total of 104 wounds in 86 patients were included. Burns were the most common etiology (40.7%), followed by chronic wounds (19.8%), infections (17.4%), trauma (15.1%), and tumors (9.3%). The mean wound area treated with BTM was 725 cm² (± 937.6). Complete BTM integration occurred in 74.1% of wounds, partial integration in 9.6%, and BTM loss in 16.3%. Infectious complications occurred in 15.4% and skin graft failure following successful BTM integration in 6.9%. Peripheral arterial disease and exposed tendons were significantly more frequent in cases of BTM loss in univariate analysis but were not independent predictors in multivariable analysis. BTM represents a reliable reconstructive option for complex full-thickness wounds across diverse etiologies, demonstrating high integration and graft success rates. Peripheral arterial disease and exposed tendons may increase the risk of BTM loss, although independent predictive value was not confirmed.