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Updated: Aug 15, 2026
09:34
An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
Host-pathogen interactions in tuberculosis: from immunological mechanisms to translational applications
Qiyao Chai1, Zehui Lei1, Cui Hua Liu1,2
1Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
Cell Insight
|August 14, 2026
Summary
Tuberculosis (TB) research explores the complex interplay between Mycobacterium tuberculosis (Mtb) and the host immune system. Advances in multi-omics and single-cell technologies offer new strategies for TB prevention and treatment.
Area of Science:
- Immunology
- Infectious Diseases
- Microbiology
Background:
- Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a leading global infectious disease killer.
- Host-Mtb interactions are complex, hindering effective prevention and control strategies.
- Recent technological advancements offer new insights into Mtb infection dynamics and host immune responses.
Purpose of the Study:
- To review current knowledge on Mtb-host immunological interplay.
- To discuss host-Mtb interactions from three perspectives: immunity balance, local/systemic coordination, and immune dysregulation in TB comorbidities.
- To highlight translational opportunities for TB control.
Main Methods:
- Review of multi-omics, spatiotemporal biology, and single-cell technologies.
- Analysis of host-Mtb immunological interplay.
- Integration of recent discoveries and unresolved questions in TB pathogenesis.
Main Results:
- Insights into the balance between protective immunity and immunopathology in TB.
- Understanding of local and systemic immunity coordination during Mtb infection.
- Identification of Mtb-induced immune dysregulation contributing to TB comorbidities.
Conclusions:
- Targeting the host-Mtb interface offers translational opportunities for TB control.
- Development of predictive biomarkers, next-generation vaccines, and precision treatment strategies are crucial.
- An updated overview of TB pathogenesis aims to spur transformative tools for TB control.
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