Related Experiment Video
Updated: Aug 15, 2026

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
Published on: September 12, 2019
Current status and targeted therapies in endometrial cancer: Molecular classification-driven treatment strategies
Xinyu Li1,2, Jie Liu1, Fang Huang2
1Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, School of Pharmacy, Shihezi University, Shihezi, Xinjiang Uyghur Autonomous Region 832003, P.R. China.
Abstract:
Endometrial cancer (EC) is one of the most common gynecological malignancies worldwide. Although numerous patients are diagnosed at an early stage with favorable outcomes, advanced and metastatic disease remains associated with limited therapeutic options and poor prognosis. Advances in molecular characterization have reshaped the understanding of EC pathogenesis and enabled the development of classification-driven treatment strategies. The present review summarized current standard therapies, including surgery, chemotherapy and radiotherapy, and highlighted the growing role of molecularly targeted treatments. The integration of pathogenetic, histopathological and molecular classifications provides a framework for identifying actionable alterations. Key oncogenic signaling pathways, including PI3K/AKT/mTOR and RAS/RAF/MEK/ERK, were discussed in the context of therapeutic targeting and precision medicine. In addition, emerging strategies, particularly immunotherapy and combination approaches, were addressed. A deeper understanding of molecular heterogeneity may facilitate individualized treatment selection and improve clinical outcomes in patients with EC.
Related Concept Videos
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Treatment Resistant Cancers
Mitogens and the Cell Cycle
Treatment Resistent Cancers
