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Updated: Aug 15, 2026
09:13
Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy
Published on: November 1, 2011
Persistent circulation of Rift Valley fever virus lineage C in Rwanda, 2022-2025
Jean Claude Udahemuka1,2, Hayley Cassidy3, Leonard Schuele3
1Department of Veterinary Medicine, University of Rwanda, Nyagatare, Rwanda.
One Health (Amsterdam, Netherlands)
|August 14, 2026
Summary
Rift Valley fever virus outbreaks in Rwanda are due to sustained local circulation, not new introductions. Continuous genomic surveillance is crucial for endemic areas to monitor transmission dynamics.
Area of Science:
- Veterinary Virology
- Genomic Epidemiology
- One Health Surveillance
Background:
- Rwanda has faced repeated Rift Valley fever virus (RVFV) outbreaks over the past decade.
- Understanding the origin of these outbreaks is critical for effective control strategies.
Purpose of the Study:
- To determine if recent RVFV outbreaks in Rwanda originated from repeated introductions or sustained local transmission.
- To investigate the genomic diversity and evolutionary history of RVFV in Rwanda.
Main Methods:
- Whole-genome sequencing of RVFV from livestock samples collected between 2022 and 2025.
- Utilized Nanopore sequencing technology for rapid and comprehensive genomic data generation.
- Phylogenetic analysis to infer transmission patterns and origins.
Main Results:
- Genomic analyses revealed sustained local circulation of RVFV lineage C.
- Evidence suggests ongoing transmission driven by sporadic spillover events, rather than repeated introductions.
- The study provides a detailed genomic history of RVFV in the region.
Conclusions:
- Recent RVFV outbreaks in Rwanda are primarily driven by sustained local transmission.
- Continuous genomic surveillance within a One Health framework is essential for managing RVFV in endemic regions.
- Findings highlight the importance of monitoring livestock populations for early detection and response.
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