Related Experiment Video
Updated: Aug 15, 2026

Using Reverse Genetics to Manipulate the NSs Gene of the Rift Valley Fever Virus MP-12 Strain to Improve Vaccine Safety and Efficacy
Published on: November 1, 2011
Persistent circulation of Rift Valley fever virus lineage C in Rwanda, 2022-2025
Jean Claude Udahemuka1,2, Hayley Cassidy3, Leonard Schuele3
1Department of Veterinary Medicine, University of Rwanda, Nyagatare, Rwanda.
Abstract:
Rwanda has experienced recurrent Rift Valley fever virus outbreaks in the last decade. In this study, we investigated whether these outbreaks resulted from repeated introductions or sustained local circulation. We generated RVFV whole-genome sequences from livestock samples collected between 2022 and 2025 using Nanopore sequencing. Genomic analyses indicated the outbreaks resulted from sustained local circulation of lineage C rather than repeated introductions, suggesting ongoing transmission likely driven by sporadic spillover. This study underscores the importance of continuous genomic One Health surveillance in endemic settings.
Related Concept Videos
Rabies
Arboviral Encephalitis
Respiratory Syncytial Virus Disease
Yellow Fever
Infectious Diseases and Their Occurrence

