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Long-Term Outcomes of Endoscopic Transpapillary Gallbladder Stenting for Symptomatic Cholelithiasis
Kazuki Natsui1,2, Seiichi Yoshikawa1, Kazuya Takahashi2
1Department of Gastroenterology, Nagaoka Red Cross Hospital, Nagaoka, Niigata, Japan.
Gastro Hep Advances
|August 14, 2026
Summary
Endoscopic transpapillary gallbladder stenting (ETGS) is safe for high-risk patients with gallstones. The IYO-stent significantly reduced late adverse events, improving long-term outcomes.
Area of Science:
- Gastroenterology
- Minimally Invasive Surgery
- Endoscopic Procedures
Background:
- Long-term outcomes of endoscopic transpapillary gallbladder stenting (ETGS) for symptomatic cholelithiasis remain unclear.
- Patients with high surgical risks often have limited treatment options for symptomatic cholelithiasis.
Purpose of the Study:
- To evaluate the long-term safety and effectiveness of ETGS in patients with symptomatic cholelithiasis and high surgical risks.
- To identify risk factors for late adverse events (LAEs) following ETGS.
Main Methods:
- A retrospective single-center study of 100 patients who underwent ETGS between January 2017 and December 2023.
- Assessment of patient characteristics, endoscopic procedures, stent types, and clinical outcomes, focusing on LAEs occurring >2 weeks postoperatively.
- Analysis of LAE frequency, LAE-free survival rates, and multivariate analysis to determine risk factors for LAEs.
Main Results:
- The overall LAE rate was 27.0%, with common events including cholangitis and cholecystitis.
- Estimated 1, 2, and 3-year LAE-free survival rates were 88.7%, 80.3%, and 76.7%, respectively.
- IYO-stent placement was independently associated with a significantly decreased risk of LAEs (HR 0.19, P < .01) compared to endoscopic nasobiliary drainage tubes.
Conclusions:
- Long-term ETGS, with regular follow-up, is a safe and effective option for high-risk patients with symptomatic cholelithiasis.
- The use of the IYO-stent demonstrates a potential to improve long-term LAE-free survival by reducing the risk of late adverse events.
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