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Multiple Painful Papules on the Arm: A Clue to Reed Syndrome
Simona Kogan1, Mindy Kresch-Vatch2, Tara Howard3
1Dermatology, Philadelphia College of Osteopathic Medicine, Philadelphia, USA.
Multiple painful piloleiomyomas can signal hereditary leiomyomatosis and renal cell carcinoma (HLRCC). Early recognition of these skin lesions is crucial for genetic evaluation and cancer surveillance.
Area of Science:
- Dermatology
- Oncology
- Genetics
Background:
- Piloleiomyomas are benign tumors arising from smooth muscle fibers.
- Multiple cutaneous piloleiomyomas can be associated with hereditary cancer syndromes.
- Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is an autosomal dominant cancer predisposition syndrome.
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