Related Experiment Video

Updated: Aug 15, 2026

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
08:45

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

Published on: December 28, 2017

First Case of Candidemia With Fluconazole-Resistant Candida albicans and Y132H Mutations in ERG11 Gene From Pakistan

Nosheen Nasir1, Joveria Farooqi2, Iffat Khanum1

  • 1Department of Medicine, Aga Khan University, Karachi, Pakistan, aku.edu.

Case Reports in Infectious Diseases
|August 14, 2026
PubMed

Insights

This case report details the first instance of fluconazole-resistant Candida albicans bloodstream infection in Pakistan, linked to ERG11 gene mutations. It highlights the growing threat of antifungal resistance in clinical settings.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Genetics

Background:

  • Candida albicans is a critical fungal pathogen globally.
  • Fluconazole resistance in C. albicans is a growing concern worldwide.
  • Antifungal resistance epidemiology is evolving in Pakistan.

Purpose of the Study:

  • To report the first case of candidemia with fluconazole-resistant C. albicans in Pakistan.
  • To identify the genetic basis of fluconazole resistance in the isolate.
  • To emphasize the need for antifungal stewardship.

Main Methods:

  • Case report of a patient with septic shock and Fournier's gangrene.
  • Blood culture to identify the causative agent.
  • Molecular analysis to detect mutations in the ERG11 gene.

Main Results:

  • Isolation of fluconazole-resistant Candida albicans from blood cultures.
  • Identification of the Y132H mutation in the ERG11 gene.
  • The patient had multiple comorbidities including diabetes and recent COVID-19.

Conclusions:

  • This is the first documented case of candidemia with fluconazole-resistant C. albicans in Pakistan.
  • The Y132H mutation in ERG11 is associated with fluconazole resistance.
  • Urgent need for antifungal stewardship to combat rising resistance.
Keywords:
ERG11 geneY132H mutationfluconazole-resistant Candida albicans

More Related Videos

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis08:48

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Published on: March 19, 2019

Generation of Fluorescent Protein Fusions in Candida Species09:27

Generation of Fluorescent Protein Fusions in Candida Species

Published on: March 4, 2017

Related Concept Videos

Candidiasis01:20

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...