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Clinical Significance and Subtype Distribution of Blastocystis Infection with Colonoscopy Findings
Erdogan Malatyali1, Ismail Taskiran2, Levent Durmus Guler2
1Department of Parasitology, Faculty of Medicine, Aydin Adnan Menderes University, Aydin, Turkey.
Blastocystis was detected in patients undergoing colonoscopy, with higher prevalence in males with normal findings. Subtype ST3 was most common, suggesting a potential association with a healthy gut.
Area of Science:
- Gastroenterology
- Microbiology
- Parasitology
Background:
- The role of Blastocystis in intestinal disorders is debated.
- Understanding its clinical significance and subtype distribution is crucial.
Purpose of the Study:
- To clarify the clinical significance of Blastocystis.
- To determine Blastocystis subtype distribution in relation to colonoscopic findings.
Main Methods:
- Fecal samples from 250 adult patients (125 with abnormalities, 125 normal) were analyzed.
- Blastocystis detection used microscopy and SSU rRNA gene amplification.
- Subtyping was based on exact database matches.
Main Results:
- Blastocystis was detected in 10.4% (microscopy) and 12.8% (molecular).
- Prevalence did not differ significantly between patients with abnormalities and controls.
- Males with normal findings showed higher Blastocystis prevalence (19.6%) than those with abnormalities (7.7%).
- ST3 was the predominant subtype (59.4%), followed by ST2 (21.8%) and ST1 (18.7%).
Conclusions:
- Results question the association of Blastocystis with colonic abnormalities.
- A potential association with a healthy gut warrants further investigation.
- ST3 is the predominant subtype, aligning with global data.
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