Related Experiment Video
Updated: Aug 15, 2026

A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix
Published on: January 4, 2017
Apical extracellular matrix development
Maxwell G Heiman1,2, Meera V Sundaram3
1Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Abstract:
The apical extracellular matrix (aECM) plays crucial roles during morphogenesis and forms the interface through which tissues communicate with the environment. The aECM exhibits complex molecular composition and structure, including multi-layered organization, localized cell-type-specific specializations, three-dimensional elaborations and dynamic temporal remodeling. Yet, until recently, the aECM received relatively little attention compared to the much more well-studied basal ECM (i.e. the basement membrane and stromal matrix). Here, we discuss aECM composition and variation across species, and summarize emerging ideas from a growing community of aECM researchers related to potential mechanisms that control aECM development.
Related Concept Videos
The Extracellular Matrix
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
The Extracellular Matrix
Overview of Cell-Matrix Interactions
Extracellular Matrix
Cell-matrix's Response to Mechanical Forces
Anchoring junctions mechanically attach a cell to the...
Cell Motility through Blebbing
Blebbing Through the Matrix
In multicellular...
