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Updated: Aug 15, 2026

Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence
10:52

Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence

Published on: December 23, 2022

Pediatric Stroke Due to Thromboembolism Secondary to Prominent Eustachian Valve With Patent Foramen Ovale

Sindhu V Nambiar1, Thomas Mathew2, Mohammed Shakeebuddin Kashif3

  • 1Department of Neurology and Radiology, Manipal Hospitals, Bangalore, Karnataka, India.

JACC. Case Reports
|August 14, 2026
PubMed

Insights

Pediatric strokes can stem from paradoxical embolism through a patent foramen ovale (PFO) during a Valsalva maneuver. Closure of the PFO may be warranted in select cases, especially with a large Eustachian valve.

Area of Science:

  • Pediatric Neurology
  • Cardiology
  • Vascular Medicine

Background:

  • Pediatric strokes have varied etiologies.
  • Thromboembolism can paradoxically occur in children with cardiac defects featuring a right-to-left shunt.
Abstract

Keywords:
Eustachian valvecardioembolismpatent foramen ovalepediatric strokepercutaneous closureright to left shuntvalsalva maneuver

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