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08:45
Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
First Reported Neonatal Invasive Candidozyma auris (Candida auris) Infection in Brazil: Successful Management,
Angelica Zaninelli Schreiber1,2, Ana Luisa Perini Leme Giordano3, Barbara Cipulo Legabão3
1Pathology Department, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil. zaninele@unicamp.br.
Mycopathologia
|August 14, 2026
Summary
The first neonatal invasive Candida auris infection in Brazil was successfully managed in an extremely preterm infant. Early diagnosis and antifungal treatment prevented further spread in the neonatal intensive care unit.
Area of Science:
- Infectious Diseases
- Neonatal Medicine
- Mycology
Background:
- Candida auris is an emerging multidrug-resistant fungal pathogen.
- Neonates, especially preterm infants, are vulnerable to invasive fungal infections.
- The emergence of C. auris in Brazil highlights the need for vigilance in neonatal intensive care units.
Purpose of the Study:
- To report the first case of invasive Candida auris infection in a neonate in Brazil.
- To detail the clinical course and management of this infection.
- To evaluate the effectiveness of infection control measures.
Main Methods:
- Retrospective case description of an extremely preterm infant.
- Monitoring of clinical signs, symptoms, and microbiological findings.
- Antifungal susceptibility testing and evaluation of treatment response.
Main Results:
- A 25+4-week male neonate developed bloodstream and urinary C. auris infection within the first week of life.
- Progressive resistance to amphotericin B in urinary isolates necessitated the addition of fluconazole.
- No secondary cases of C. auris infection occurred in the neonatal intensive care unit.
Conclusions:
- Early diagnosis and prompt initiation of appropriate antifungal therapy are crucial for successful outcomes.
- Serial antifungal susceptibility testing guided treatment adjustments.
- Effective infection control measures prevented nosocomial transmission.
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