Related Experiment Video
Updated: Aug 16, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Organocatalytic Enantioselective Synthesis of C-N Axially Chiral N-Arylindole Amino Esters via Oxidative
Guowei Yuan1, Jinna Han1, Yanqi Fan2
1Institute of Advanced Materials, School of Chemistry and Molecular Engineering, Nanjing Tech University, 30 South Puzhu Road, Nanjing211816, China.
Abstract:
A highly efficient N-heterocyclic carbene (NHC)-catalyzed dynamic kinetic resolution strategy has been developed for the selective oxidative esterification of N-sulfonamide aminoaldehydes. With a catalyst loading as low as 3 mol %, a broad range of structurally diverse N-arylindole amino esters featuring a C-N chiral axis were synthesized in excellent yields and enantioselectivities. The reaction exhibits broad substrate scope and has been successfully performed on a gram scale, demonstrating its high efficiency and practical utility.
More Related Videos
06:31Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access to a New Class of Low Molecular Weight Gelators
Published on: November 27, 2015
07:30A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
Published on: January 21, 2020
Related Concept Videos
Stereochemical Effects of Enolization
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide
Alkylation of β-Diester Enolates: Malonic Ester Synthesis
Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction
Sharpless Epoxidation
Alkylation of β-Ketoester Enolates: Acetoacetic Ester Synthesis