Rearranged Jatrophane Diterpenoids from Euphorbia helioscopia with 5/6/6/4 and 5/6/6/5 Fused Skeletons and Potent

Xiong Qiu1,2, Pan-Pan Pang3, Ting-Ting Yue1

  • 1Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Yunnan Key Laboratory of Research and Development for Natural Products, Institute of International Rivers and Eco-Security, School of Pharmacy and School of Chemical Science and Technology, Yunnan University, Kunming650500, People's Republic of China.

Organic Letters
|August 14, 2026
PubMed

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Structure of Conjugated Dienes01:16

Structure of Conjugated Dienes

Introduction
Conjugated dienes are compounds characterized by the presence of alternating double and single bonds. In a conjugated system like 1,3-butadiene, the unhybridized 2p orbital on each carbon overlaps continuously, allowing the π electrons to be delocalized across the entire molecule. In contrast, this type of overlap does not occur in cumulated and isolated dienes, such as 2,3-pentadiene and 1,4-pentadiene, respectively. Instead, the π electrons remain localized between the double...