Related Experiment Video

Updated: Aug 16, 2026

A Modified Co-Culture System for Understanding Granulosa-Theca Cell Interactions in the Bovine Ovary
07:03

A Modified Co-Culture System for Understanding Granulosa-Theca Cell Interactions in the Bovine Ovary

Published on: September 19, 2025

FOXO1 Promotes Mitophagy in Granulosa Cells by Targeting the METTL3/SMAD4 axis

Lan Luo1, Mi Tang2, Yanli Peng2

  • 1Department of TCM Gynecology, Hunan Provincial Maternal and Child Health Care Hospital, No.53, Xiangchun Road, Kaifu District, Changsha, 410008, Hunan, P.R. China. luolansci@126.com.

Cell Biochemistry and Biophysics
|August 14, 2026
PubMed
Summary

Forkhead box protein O1 (FOXO1) impairs fertility by promoting mitophagy and mitochondrial damage in ovarian granulosa cells. FOXO1 targets METTL3 to reduce SMAD4, affecting cell proliferation and apoptosis.

Keywords:
FOXO1Mitochondrial autophagyOvarian dysfunctionSMAD4m6A

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