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Advances in Cyclic Peptides Targeting G Protein-Coupled Receptors

Yingxin Zhou1, Ni Li2, Ji-Shen Zheng2

  • 1School of Basic Medicine Sciences, Wannan Medical University, Wuhu, Anhui, China.

Chembiochem : a European Journal of Chemical Biology
|August 14, 2026
PubMed
Summary

Cyclic peptides offer a powerful strategy for targeting peptide- G protein-coupled receptors (GPCRs). Their unique structures enable precise modulation of receptor interactions for drug discovery.

Keywords:
G protein‐coupled receptor drug discoveryconformational constraintcyclic peptidesmacrocyclic ligandspeptide‐responsive GPCRs

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