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mRNA-LNP therapeutics for obesity: weight loss with metabolic repair

Jun Liao1, Lukas Farbiak2,3, Daniel J Siegwart4,5

  • 1Department of Pharmacy and Pharmaceutical Sciences, Faculty of Science, National University of Singapore, Singapore, Singapore.

Nature Reviews. Endocrinology
|August 14, 2026
PubMed
Abstract

No abstract available in PubMed .

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Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes: