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A PRISMA-guided systematic review of pharmacogenetic anticancer clinical trials registered on clinicaltrials.gov

Ahmed M Ashour1, Aliah Alhayyan2, Rawan Alhayyan3

  • 1Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.

Medicine
|August 15, 2026
PubMed
Abstract

Insights

Pharmacogenetics is advancing precision oncology by guiding cancer treatments. This review of clinical trials shows a rise in biomarker use, but global representation and late-phase studies need expansion for wider implementation.

Area of Science:

  • Oncology
  • Pharmacogenetics
  • Clinical Trials

Background:

  • Pharmacogenetics is crucial for personalized cancer therapy based on genetic profiles.
  • ClinicalTrials.gov is a key resource for tracking global pharmacogenetic anticancer trial trends.
  • This review analyzes trends in study design, cancer types, biomarkers, interventions, and geographic distribution.

Conclusions:

  • Pharmacogenetic approaches are increasingly integrated into anticancer trials, advancing precision oncology.
  • Broader global representation and more late-phase trials are needed.
  • Standardized biomarker integration is essential for wider clinical adoption.
Keywords:
anticancer trialsclinicaltrials.govoncologypharmacogeneticsprecision medicinesystematic review

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