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Updated: Aug 16, 2026

Assessment of Gut Barrier Integrity in Mice Using Fluorescein-Isothiocyanate-Labeled Dextran
Published on: November 18, 2022
Genetic Risk Meets the Intestinal Barrier
J L E Tearle1,2, K R James1,2
1Translational Genomics Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia.
Abstract:
Top: At increasing cellular resolution, the Alegbe et al. report that expression quantitative trait loci (eQTLs) are enriched in enhancer regions rather than promoters. They speculate that enhancer eQTLs only come into effect during certain cellular contexts, making them more tolerable. Bottom: Alegbe et al. identify an enrichment of eQTLs affecting Wnt pathway regulators in inflammatory bowel disease (IBD) epithelium, suggesting a reduced capacity for regeneration. Additionally, the authors show an enrichment of interaction eQTLs (ieQTLs) in IBD epithelium that become active only during inflammation.
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