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Polymeric Microneedle Array Fabrication by Photolithography
Published on: November 17, 2015
Sustainable Polylactic Acid-Derived Polyurethane/MXene Microneedles for Stimulus-Responsive Transdermal Delivery
Oceu D Putri1,2, Atitsa Petchsuk3, Kensuke Asukabe1
1School of Materials Science, Japan Advanced Institute of Science and Technology (JAIST), Nomi-shi, Ishikawa 923-1292, Japan.
ACS Polymers Au
|August 15, 2026
Summary
This study presents a sustainable, biodegradable microneedle platform made from recycled polylactic acid (PLA) and MXene. The microneedles offer controlled drug release and potential for wound care through photothermal and antioxidant properties.
Area of Science:
- Biomedical Engineering
- Materials Science
- Sustainable Chemistry
Background:
- Next-generation biomedical materials require a blend of sustainability and advanced functionality.
- Current transdermal delivery systems often lack eco-friendly components and stimuli-responsive capabilities.
Purpose of the Study:
- To develop a biodegradable microneedle (MN) platform using chemically recycled polylactic acid (PLA).
- To incorporate Ti3C2Tx MXene for enhanced functionality, including photothermal responsiveness and antioxidant properties.
- To evaluate the platform's suitability for transdermal drug delivery and wound management.
Main Methods:
- Synthesized polyurethane (PU) via chemical recycling of PLA waste.
- Incorporated delaminated Ti3C2Tx MXene into the PU matrix.
- Conducted in vitro assessments for skin penetration, photothermal cycling stability, antioxidant capacity, and cytocompatibility.
Main Results:
- Developed a flexible, mechanically robust, and biodegradable MN platform.
- Achieved heat-triggered model drug release using near-infrared (NIR) irradiation due to MXene.
- Demonstrated antioxidant capacity and improved mechanical strength.
- Confirmed effective skin penetration and cytocompatibility.
Conclusions:
- Established a sustainable, multifunctional MN platform by upcycling PLA waste.
- The platform integrates circular polymer design with stimuli-responsive performance for transdermal applications.
- This work supports future development of advanced, eco-friendly transdermal drug delivery systems and wound management solutions.
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