Related Experiment Video
Updated: Aug 16, 2026
07:35
Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
Published on: July 8, 2025
Lansoprazole-Induced Myoclonus
R N Komal Kumar1, Vijay K Sharma2,3
1Department of Neurology, Yashoda Hospital, Secunderabad, Telangana, India.
Tremor and Other Hyperkinetic Movements (New York, N.Y.)
|August 15, 2026
Summary
Proton pump inhibitors like lansoprazole are generally safe, but can rarely cause neurological issues. A case study showed a patient experienced asterixis shortly after taking lansoprazole, which resolved upon stopping the medication.
Area of Science:
- Neurology
- Pharmacology
- Gastroenterology
Background:
- Proton pump inhibitors (PPIs) are widely used for acid-related gastrointestinal disorders.
- While generally safe, rare neurological side effects of PPIs have been reported.
- Lansoprazole is a common PPI, and its safety profile is well-established.
Purpose of the Study:
- To report a case of lansoprazole-induced neurological dysfunction.
- To highlight the potential for asterixis as a rare adverse effect of lansoprazole.
Main Methods:
- Case report presentation.
- Clinical observation of patient symptoms and response to medication withdrawal.
Main Results:
- A middle-aged man developed bilateral asterixis within hours of his first lansoprazole dose.
- Asterixis resolved rapidly after discontinuation of lansoprazole.
Conclusions:
- Lansoprazole can rarely be associated with neurological dysfunction, specifically asterixis.
- Prompt recognition and discontinuation of the drug can lead to rapid symptom resolution.
Related Concept Videos
01:28Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists
Prokinetic agents are specialized medications that stimulate gastrointestinal (GI) motility, promoting food movement through the GI tract. Dopamine, an inhibitory neurotransmitter, plays a significant role in this process, reducing GI motility and indirectly controlling the speed of digestion. Dopamine receptor antagonists, such as metoclopramide and domperidone, offer a unique advantage as prokinetic agents. By blocking the dopamine receptors, these drugs increase GI motility, improving food...
01:13Acid Suppressive Drugs for Peptic Ulcer Disease: Proton Pump Inhibitors
Peptic ulcers, often induced by H. pylori infections or NSAID usage, arise from disruptions in the delicate balance of gastric acid production. Peptic ulcers stem from heightened gastric acid levels due to H. pylori infections or NSAID use. The protective mucus layer diminishes in the presence of these factors, allowing gastric acid to erode the stomach lining and form ulcers.
Gastric acid, a potent cocktail of hydrogen and chloride ions, is produced in specialized parietal cells within the...
Gastric acid, a potent cocktail of hydrogen and chloride ions, is produced in specialized parietal cells within the...
01:28Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists
Histamine H2 receptors, which are intricately located on the basolateral membrane of parietal cells, play a crucial role in modulating gastric acid secretion. When released from enterochromaffin-like cells, histamine engages H2 receptors, initiating the cyclic AMP (cAMP) pathway. In this pathway, adenylyl cyclase converts ATP into cAMP, elevating intracellular cAMP levels. The activation of protein kinase A follows, stimulating the proton pump. This stimulation prompts the secretion of hydrogen...
01:31Acid Suppressive Drugs for Peptic Ulcer Disease: Antacids
In the complex environment of the gastric lumen, excessive acid secretion can lead to the formation or worsening of ulcers within the delicate mucosal layer. Antacids, such as sodium bicarbonate and calcium carbonate, provide relief by neutralizing this acid, transforming it into harmless salt and water. This neutralization process raises the gastric pH from a highly acidic level of 1 to a more basic 3-4, reducing the acidity within the stomach.
However, this neutralization reaction between...
However, this neutralization reaction between...
01:21Skeletal Muscle Relaxants: Adverse Effects
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
Unlike...
01:14Antiepileptic Drugs: Glutamate Antagonists
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...