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Prevalence and Factors Associated With Achlorhydria Among Patients With Gastric Cancer: A Two-Year Cross-Sectional
A K M Mustakim Billah1, Sajib Chandra Mandal2, Rumana Parveen3
1Department of Surgery, Dhaka Medical College and Hospital, Dhaka, BGD.
Cureus
|August 15, 2026
Summary
Achlorhydria (absent gastric acid) affects 38% of gastric cancer patients. Female sex, anemia, and proximal tumor location are associated with this condition.
Area of Science:
- Gastroenterology
- Oncology
Background:
- Achlorhydria (absent gastric acid secretion) is linked to nutritional issues and gastric injury.
- Its role in gastric cancer, especially in South Asia, needs more research.
Purpose of the Study:
- To determine the prevalence of achlorhydria in gastric cancer patients.
- To identify factors associated with achlorhydria in this population.
Main Methods:
- A cross-sectional study of 100 gastric adenocarcinoma patients in Bangladesh.
- Achlorhydria defined as fasting intragastric pH >6.0.
- Multivariable logistic regression analyzed associations.
Main Results:
- Prevalence of achlorhydria was 38.0%.
- Associated factors included female sex, low hemoglobin (anemia), and proximal/body tumor location.
- Proton pump inhibitor use showed a univariate association.
Conclusions:
- Achlorhydria is common in gastric cancer patients.
- Female sex, anemia, and tumor location are independently associated.
- Further prospective studies are needed to confirm causality.
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