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Updated: Aug 17, 2026

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization
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Published on: December 23, 2020

SARS-CoV-2-induced IgG repertoires shape T cell responses, microRNA regulation, and autoreactivity according to

Fabio da Ressureição Sgnotto1, Nicolle Rakanidis Machado2, Lais Alves do Nascimento2

  • 1Post Graduation Program in Health Sciences, Santo Amaro University (UNISA), São Paulo, Brazil.

Journal of Translational Autoimmunity
|August 16, 2026
PubMed

SARS-CoV-2 infection can generate IgG repertoires with functions beyond viral neutralization. We purified IgG from non-exposed healthy controls, moderate and severe COVID-19 patients, and IVIg, and assessed their effects on healthy-donor PBMCs. COVID-19 IgG bound CD4+ and CD8+ T cells without inducing apoptosis. Severe-COVID IgG reduced Treg frequencies, enhanced IFN-γ production, and expanded autoreactivity toward proteins linked to proteostasis, whereas moderate-COVID IgG promoted CD8+ IL-22 and selective miRNA downregulation. These findings identify disease-severity-associated antibody-mediated immune modulation in vitro and motivate patient-resolved longitudinal validation.

Keywords:
AutoreactivityCD4+ T cellsCD8+ T cellsCOVID-19CytokinesDisease severityIgG repertoireImmune modulationSARS-CoV-2microRNAs

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