Effects of Safe Early Intervention Approach: A 3-Year Follow-Up

Bulent Elbasan1, Ecem Yildiz Cangur1, Pelin Atalan Efkere1

  • 1Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Gazi University, Ankara, Turkey.

Brain and Behavior
|August 17, 2026
PubMed

Insights

The SAFE early intervention approach and Neurodevelopmental Treatment (NDT) both support infant development. SAFE showed potential advantages in sensory processing, though no significant differences in overall developmental trajectories were found between the two approaches.

Area of Science:

  • Developmental Pediatrics
  • Early Intervention Strategies
  • Neurodevelopmental Risk

Background:

  • Early intervention is crucial for improving developmental outcomes in at-risk infants.
  • The SAFE (Sensory and Adaptive Functioning Enhancement) approach has demonstrated effectiveness across various developmental domains.
  • This study provides a 3-year follow-up to compare the long-term outcomes of the SAFE approach.

Purpose of the Study:

  • To comparatively report the 3-year follow-up outcomes of the SAFE early intervention approach.
  • To assess the long-term efficacy of the SAFE intervention compared to Neurodevelopmental Treatment (NDT).
  • To evaluate developmental trajectories and sensory processing in infants receiving either SAFE or NDT.

Main Methods:

  • Follow-up study including 2- and 3-year-old children identified with neurodevelopmental risk.
  • Interventions compared: SAFE early intervention approach vs. Neurodevelopmental Treatment (NDT)-based intervention.
  • Development assessed using Bayley Scales of Infant and Toddler Development (Bayley-III); sensory processing evaluated with Dunn's Sensory Profile.

Main Results:

  • Both SAFE and NDT groups showed significant cognitive and language score improvements from 2 to 3 years.
  • No significant differences in cognitive, language, or motor scores were found between SAFE and NDT groups.
  • SAFE group demonstrated significant advantages in selected sensory processing domains at both 2 and 3 years.

Conclusions:

  • Both SAFE and NDT interventions positively influenced developmental progress over time.
  • While developmental trajectories did not differ significantly between groups, SAFE showed promise in enhancing sensory processing.
  • Larger sample sizes and extended follow-up are recommended to validate these findings.
Abstract

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