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Association Between Follow-Up Mean Blood Pressure and Blood Pressure Control: A Meta-Regression Analysis of 101

Abdul Salam1,2,3, Rupasvi Dhurjati1, Rashmi Pant1

  • 1The George Institute for Global Health, Hyderabad, Telangana, India (A.S., R.D., R.P., S.K.T., K.N., S.R., A.M., K.V., E.H.).

Hypertension (Dallas, Tex. : 1979)
|August 17, 2026
PubMed

Insights

Achieving blood pressure control is crucial for hypertension management. Lowering systolic blood pressure below 125 mm Hg is associated with approximately 80% of patients reaching their blood pressure control goals.

Area of Science:

  • Cardiovascular Medicine
  • Clinical Trials
  • Hypertension Research

Background:

  • The precise mean blood pressure (BP) threshold for achieving BP control (<140/90 mm Hg) in most patients remains unclear.
  • Understanding this relationship is vital for effective hypertension management strategies.

Purpose of the Study:

  • To assess the association between mean BP and BP control.
  • To analyze data from randomized clinical trials (RCTs) to quantify this relationship.

Main Methods:

  • A systematic literature search identified individual and cluster RCTs involving adults randomized to BP-lowering interventions.
  • Linear regression analysis was employed to evaluate the association between mean BP and BP control rates.

Main Results:

  • Analysis of 101 RCTs (65 iRCTs, 36 cRCTs) revealed a strong correlation between mean systolic BP (SBP) and BP control.
  • A 1 mm Hg reduction in mean SBP was linked to an approximate 2% increase in BP control, consistent across various subgroups.
  • Mean SBP levels of 120-135 mm Hg corresponded to BP control rates between 55% and 85%.

Conclusions:

  • A systolic BP below 125 mm Hg was associated with achieving BP control in approximately 80% of patients.
  • These findings offer valuable insights for hypertension guidelines, clinical practice, and public health programs.
Abstract

Keywords:
blood pressurecardiovascular diseaseclinical trials, randomizedhypertension

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