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Updated: Aug 18, 2026

Prehospital Thrombolysis: A Manual from Berlin
Published on: November 26, 2013
Intraarterial Thrombolysis: Past, Present, Future
Felix Ng1,2, Chengchuan Wu1, Ángel Chamorro3
1Department of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Victoria, Australia (F.N., C.W., B.Y., B.C.V.C.).
None:
Suboptimal clinical outcomes are common after ischemic stroke with large vessel occlusion despite current reperfusion treatment with intravenous thrombolysis and mechanical thrombectomy. Targeting residual distal arterial and microvascular occlusions with intraarterial thrombolysis has recently gained substantial interest as an adjunct to improve cerebral tissue perfusion. While recent trials provide promise in selected patients with anterior-circulation stroke, further high-quality, large-scale studies and pooled individual-patient analyses are needed. This review summarizes the evolving role of intraarterial thrombolysis over the past 3 decades and projects potential developments.
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