Related Experiment Videos

Association between red blood cell distribution width and prediabetes: evidence from a single center cohort study

Tuba Taslamacioglu Duman1, Burcin Meryem Atak Tel1, Satilmis Bilgin1

  • 1Internal Medicine Department of Abant Izzet, Baysal University Hospital, Bolu, Turkey.

Current Medical Research and Opinion
|August 17, 2026
PubMed

Insights

Red cell distribution width (RDW) is significantly higher in individuals with prediabetes compared to healthy controls. Elevated RDW is an independent predictor of prediabetes, suggesting its role in cardiometabolic health changes.

Area of Science:

  • Hematology
  • Endocrinology
  • Internal Medicine

Background:

  • Prediabetes is linked to chronic inflammation.
  • Hemogram parameters like RDW and MPV are associated with inflammatory conditions.

Purpose of the Study:

  • To compare hemogram parameters between prediabetes subjects and healthy volunteers.
  • To investigate the association of RDW and MPV with prediabetes.

Main Methods:

  • Retrospective analysis of 324 subjects (172 prediabetes, 152 controls).
  • Comparison of median RDW and MPV between groups.
  • Correlation analysis of RDW with FPG, HbA1c, triglyceride, and albumin.
  • Regression analysis to identify independent predictors of prediabetes.

Main Results:

  • Prediabetes group showed significantly higher median RDW (15.3%) compared to controls (14.75%).
  • Prediabetes group had significantly lower median MPV (7.9 fL) than controls (8.59 fL).
  • RDW, not MPV, correlated with FPG, HbA1c, triglyceride, and albumin.
  • RDW was an independent predictor of prediabetes (OR: 1.6).

Conclusions:

  • RDW is elevated in prediabetes and serves as an independent predictor.
  • RDW may reflect cardiometabolic health alterations associated with prediabetes development.
Abstract

Keywords:
Mean Platelet VolumePrediabetesblood glucoseinflammationred cell distribution width

Related Concept Videos

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis01:25

Type II Diabetes Mellitus III: Clinical Manifestations and Diagnosis

Type 2 diabetes mellitus develops gradually and is often asymptomatic in early stages.Clinical ManifestationsWhen symptoms appear, they include fatigue, blurred vision, pruritus, delayed wound healing, and recurrent infections, particularly candidal infections. Peripheral neuropathy may present as numbness or tingling in the extremities. Classic hyperglycemia symptoms—polyuria, polydipsia, and polyphagia—are less common. Most patients are overweight and frequently have associated hypertension...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is based on...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...