Related Experiment Video
Updated: Aug 18, 2026
Bioinspired Soft Robot with Incorporated Microelectrodes
Published on: February 28, 2020
Dual-Responsive Hydrogels Integrate Bioelectrical Stimulation and Piezo-Photocatalysis for Regenerative Treatment of
Baoying Dai1,2, Wenxuan Qie1, Xiaoye Li3
1State Key Laboratory of Flexible Electronics (LoFE) and Institute of Advanced Materials (IAM), Jiangsu Provincial Industrial Technology Engineering Center for Flexible Mechatronics and Energy Systems, Jiangsu Key Laboratory of Smart Biomaterials and Theranostic Technology, Nanjing University of Posts and Telecommunications, Nanjing, China.
None:
Infected wounds represent a formidable clinical challenge, as persistent bacterial colonization and disrupted bio-signaling collectively hinder effective tissue repair. Conventional passive dressings lack the capacity to actively modulate this complex microenvironment. Here, we report a wireless, dual-responsive hydrogel (PVA/P(VDF-TrFE)/BiOClBr@PDA, PPBP) based on porous poly(vinyl alcohol) (PVA), piezoelectric poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)), and polydopamine-modified bismuth oxybromide chloride (BiOClBr@PDA). The constructed hydrogel orchestrates piezoelectric stimulation and piezo-photocatalysis to simultaneously eradicate infection and accelerate tissue regeneration. Under concurrent ultrasonic and optical stimulation, this platform efficiently transduces mechanical and light energy into therapeutic electrical cues and reactive oxygen species (ROS). This dual-mode activation enables enhanced antibacterial efficacy against diverse bacterial strains, significantly outperforming single-mode treatments while maintaining favorable biocompatibility. In an infected wound model, the constructed composite hydrogel PPBP effectively inhibits bacteria and attenuates inflammatory responses via controlled ROS generation, while piezoelectric stimulation supports re-epithelialization and collagen deposition. Together, these effects promote accelerated and structurally improved wound healing. This work establishes a paradigm for utilizing multi-source energy-responsive hydrogels as an active strategy for regulating infected wound environments and supporting functional skin regeneration.