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Updated: Aug 19, 2026

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
07:41

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure

Published on: February 8, 2022

Clinical and Hemodynamic Profile of Patients Undergoing Early Closure of Atrial Septal Defect: A Systematic Review

Paolo Ferrero1,2, Daniele Mosolo3, Alessandro Greco3

  • 1Azienda ospedaliera universitaria integrata AOUI, Verona, Italy. ferrerop41@gmail.com.

Pediatric Cardiology
|August 17, 2026
PubMed

Insights

Early closure of atrial septal defect (ASD) in infants may be beneficial, especially those with comorbidities. This review analyzes the safety and efficacy of early surgical and transcatheter interventions for young children with ASD.

Area of Science:

  • Pediatric Cardiology
  • Congenital Heart Disease
  • Interventional Cardiology

Background:

  • Atrial septal defect (ASD) is typically benign, managed electively in preschool children.
  • Early symptomatic presentation of ASD is rare, often linked to comorbidities like chronic lung disease.
  • Infants with large ASDs may experience respiratory issues and failure to thrive, even without pulmonary hypertension.

Purpose of the Study:

  • To systematically review and pool data on early atrial septal defect closure.
  • To analyze clinical and hemodynamic features of children undergoing early ASD intervention (weight < 15 kg or age < 2 years).
  • To evaluate the safety and efficacy of surgical versus transcatheter closure in this pediatric population.

Main Methods:

  • Systematic literature review.
  • Pooled analysis of clinical and hemodynamic data.
  • Comparative evaluation of early surgical and transcatheter ASD closure techniques.

Main Results:

  • Data synthesis on characteristics of children undergoing early ASD closure.
  • Assessment of outcomes for both surgical and transcatheter approaches in infants and young children.
  • Identification of potential benefits and risks associated with early intervention.

Conclusions:

  • Early ASD closure may be considered in specific infant populations, particularly those with bronchopulmonary dysplasia or significant hemodynamic burden.
  • Further evidence is needed to solidify the benefits of early intervention for atrial septal defects.
  • The safety and efficacy of early surgical and transcatheter closure require continued evaluation in young children.

Keywords:
Atrial septal defectClosureEarlyPooled analysisSymptoms

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