Related Experiment Video

Updated: Aug 19, 2026

Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice
06:49

Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice

Published on: February 12, 2018

Ovarian aging and systemic health: Mechanisms and emerging intervention strategies

Ying Jing1, Jing Qu2, Si Wang3

  • 1Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Aging Translational Medicine Center, Beijing Municipal Geriatric Medical Research Center, Beijing Key Laboratory of Environment and Aging, Xuanwu Hospital Capital Medical University, Beijing 100053, China.

Cell Stem Cell
|August 17, 2026
PubMed

Insights

Ovarian aging contributes to systemic aging through cellular defects and hormonal changes. Interventions targeting the ovaries may preserve fertility and extend healthspan by combating aging processes.

Area of Science:

  • Reproductive biology
  • Gerontology
  • Endocrinology

Background:

  • Ovarian aging is increasingly recognized as a potential driver of systemic aging.
  • Cellular intrinsic defects within the ovary may initiate aging signals.
  • Estrogen decline from ovarian aging significantly impacts overall physiology.

Purpose of the Study:

  • To review the intrinsic cellular defects in ovarian aging.
  • To explore the link between ovarian aging and systemic aging.
  • To discuss potential interventions for ovarian aging and its systemic effects.

Main Methods:

  • Literature review of ovarian aging mechanisms.
  • Analysis of cellular defects (genomic instability, epigenetics, mitochondrial damage, proteostasis).
  • Examination of senescence-associated secretory phenotype (SASP)-related inflammaging and fibrosis.

Main Results:

  • Ovarian aging involves genomic instability, epigenetic alterations, mitochondrial dysfunction, and proteostasis issues.
  • These defects can lead to inflammaging, fibrosis, and pro-aging signals.
  • Estrogen decline is a key endocrine disruption affecting multiple bodily systems.

Conclusions:

  • Ovarian aging contributes to systemic aging and age-related multimorbidity in females.
  • Ovary-targeted interventions, including senolytics and regenerative medicine, show promise.
  • Preserving ovarian function may extend healthspan and improve quality of life.
Keywords:
healthspan extensioninflammaginginterventionsovarian agingovarian-systemic axis

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