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Severe Checkpoint Inhibitor Pneumonitis and Lung Cancer Recurrence After Carbon-ion Radiotherapy in a Patient with
Chenran Xu1, Yiting Zheng1, Yi Wei1
1Tongde Hospital of Zhejiang Province Affiliated to Zhejiang Chinese Medical University (College of Integrated Traditional Chinese and Western Medicine Clinical Medicine), Hangzhou, Zhejiang Province, China; Key Discipline of Clinical Respiratory Medicine Integrating Traditional Chinese and Western Medicine in Zhejiang Province, Hangzhou, Zhejiang Province, China.
Abstract:
Carbon-ion radiotherapy holds promise for central lung cancer owing to its noninvasiveness and precision. We report a case of lung squamous cell carcinoma treated with neoadjuvant chemoimmunotherapy followed by carbon-ion radiotherapy. The course was complicated by severe checkpoint inhibitor pneumonitis with concurrent Pneumocystis jirovecii pneumonia and subsequent recurrence, highlighting the challenge of managing multimodality toxicities during aggressive local control.
