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High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
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Characterisation of the Novel HLA-C*16:245 Allele by Next-Generation Sequencing

Elham Harfouch1, Marilyne Gomes1, Aicha Hamdaoui1

  • 1EFS Île-de-France, Laboratoire d'Histocompatibilité et d'Immunologie Leuco-Plaquettaire, Créteil, France.

HLA
|August 17, 2026
PubMed
Abstract

Keywords:
HLA‐C*16:245IPD‐IMGT/HLA DatabaseNGSnext‐generation sequencingnovel allele

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Next-generation Sequencing03:00

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features.