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Related Experiment Videos

External mechanical work from relaxing ventricle.

H Suga

    The American Journal of Physiology
    |March 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    The pressure-volume (P-V) loop area stores potential energy. This energy can be converted to external work during ventricular relaxation if ejection occurs against a decreasing afterload at an optimal speed.

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    Area of Science:

    • Cardiovascular Physiology
    • Biomechanical Engineering

    Background:

    • The pressure-volume (P-V) area of the left ventricle represents stored mechanical potential energy.
    • This energy is generated during systole and stored at end-systole.

    Purpose of the Study:

    • To investigate the conversion of P-V area potential energy into external mechanical work during ventricular relaxation.
    • To determine the optimal speed for volume reduction to maximize work extraction.

    Main Methods:

    • Experiments were conducted on canine left ventricles.
    • Ventricular volume reduction speed was varied during relaxation.
    • External mechanical work extracted from the P-V area was measured.

    Main Results:

    • Up to 70% of the P-V area potential energy was converted to external work.

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  • Optimal conversion occurred at a specific volume reduction speed (approx. 55 ml/s for a 70g ventricle).
  • Lower or higher speeds resulted in less work extraction.

    • Conclusions:

    • The P-V area is a quantifiable measure of potential energy.
    • Isovolumic relaxation wastes this potential energy.
    • Ejection against a decreasing afterload at an optimal speed maximizes conversion of potential energy to external work.