Related Experiment Video
Updated: Aug 19, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Palladium-catalysed cyclocarbonylative Sonogashira annulation toward flavones using Mn2(CO)10 as a carbonyl source at
Shu Yang1, Jiayin Zhang1, Jun Ge1
1School of Chinese Materia Medica, Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, PR China. zcwang@tjutcm.edu.cn.
Abstract:
A facile palladium-catalysed cyclocarbonylative Sonogashira cascade reaction for flavone synthesis is disclosed herein. By utilizing Mn2(CO)10 as a solid carbonyl surrogate, this protocol completely circumvents the safety risks of high-pressure CO gas. The transformation operates efficiently at room temperature with low palladium loading and tolerates a wide range of functional groups as well as aromatic, heteroaromatic and aliphatic alkynes. The reaction proceeds via successive C-C and C-O bond formation. The methodology is readily scalable to the gram scale and enables late-stage derivatization of flavone scaffolds. This mild, safe and sustainable approach offers a powerful synthetic tool for constructing diverse flavone derivatives and related bioactive compounds.
More Related Videos
10:42Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
09:35Preparation of a Corannulene-functionalized Hexahelicene by Copper(I)-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
Published on: September 18, 2016
Related Concept Videos
Cyclohexenones via Michael Addition and Aldol Condensation: The Robinson Annulation
Cycloaddition Reactions: Overview
Cycloaddition Reactions: MO Requirements for Thermal Activation
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions
Cycloaddition Reactions: MO Requirements for Photochemical Activation
Preparation of 1° Amines: Hofmann and Curtius Rearrangement Mechanism