Experimental teratogenic lathyrism in sheep and further comparative aspects with teratogenic locoism

A comparison of the gross anatomical deviations in malformed offspring from ewes that ingested the locoweed plant or a synthetic lathyrogen during gestation revealed many similarities but also certain essential differences. Similarities included abortions, contracture or overextension of the pastern joint, permanent flexure of the carpal joint, lateral rotation of the forelimbs, osteoporosis and bone fragility, and brachygnathia. Features restricted to the lathyrogen-induced condition included spinal malformations of various kinds especially scoliosis but occasionally kyphosis and torticollis, and forelimb abduction resulting from loose scapular attachment. The loose or hypermobile stifle joint of the loco-induced condition was rare in malformed offspring from lathyrogen-fed animals.