Related Experiment Video
Updated: Aug 19, 2026

06:55
The Ex vivo Preparation of Spinal Cord Slice for the Whole-Cell Patch-Clamp Recording in Motor Neurons During Spinal Cord Stimulation
Published on: September 8, 2023
Correction: Spinal cord injury and electrical stimulation: analysis of neuroplasticity in a case report
Orcizo Francisco Silvestre1, Julia Silva E Lima Schleder1, Bruna Valentina Zuchatti2
1Faculty of Medical Sciences, UNICAMP- State University of Campinas, Campinas, Brazil.
Frontiers in Rehabilitation Sciences
|August 18, 2026
Abstract:
[This corrects the article DOI: 10.3389/fresc.2025.1557010.].
Related Concept Videos
Spinal Cord Injury ll: Pathophysiology
Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
Secondary Spinal Cord Injury llI: Pathophysiology
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
