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Hypericum A-E: five unprecedented polycyclic polyprenylated acylphloroglucinols from Hypericum lagarocladum
SiYuan Du1, ZhuoHong Cai1, MingRui Wang1
1Guangdong Provincial Key Laboratory of Translational Chinese Medicine, International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine Guangzhou China zrr586@gzucm.edu.cn fengqian@gzucm.edu.cn liuzq@gzucm.edu.cn.
Abstract:
Five new PPAPS compounds, Hypericum A-E (1-5), and twelve known compounds were isolated from Hypericum lagarocladum. The structures of these compounds were determined through a combination of methods such as mass spectrometry, ultraviolet spectroscopy, infrared spectroscopy, nuclear magnetic resonance spectroscopy and electron capture dissociation calculations. Compounds 5, 4, and 1 exhibited inhibitory activity against PTP1B with IC50 values of 6.50 ± 0.81 µM, 11.47 ± 1.06 µM, and 26.01 ± 1.42 µM, respectively, which indicated that these compounds are promising PTP1B inhibitor lead candidates.