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Multimodal balance training with rhythmical auditory cueing in Huntington's disease: A pilot randomized controlled
Tamine Tc Capato1,2, Jorik Nonnekes1,3, Jordache Ramjith4
1Department of Neurology; Department of Rehabilitation, Donders Institute for Brain, Cognition and Behavior; Centre of Expertise for Parkinson & Movement Disorders; Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.
None:
BackgroundBalance impairments in Huntington's Disease (HD) are common but difficult to treat.ObjectivesWe aimed to investigate the potential effects and feasibility of multimodal physiotherapy balance intervention in HD.MethodIn this prospective, double-blind, parallel group randomized clinical trial (phase 1pilot study), we screened 56 persons with genetically confirmed HD; 36 were assigned randomly into three groups: 1) multimodal physiotherapy balance intervention supported by rhythmical auditory stimuli (RAS-supported, n = 12); (2) multimodal physiotherapy balance intervention without rhythmical auditory stimuli (Regular, n = 12); and (3) control intervention (educational program, n = 12). Interventions were delivered for 2-months, at a low dose, 1 session/week. The primary outcome was the Mini-BESTest scored directly after the intervention. All outcomes were assessed at three time-points.ResultsDirectly post-intervention, both the RAS-supported group and the Regular group improved significantly on the Mini-BESTest score compared to the Control group (RAS-supported 4.2 (95% Confidence Interval(CI) 3.1; 5.2), p < 0.001; Regular 2.7 (CI 1.7; 3.6), p < 0.001. These improvements were retained at 6-month follow-up only for the RAS-supported group.ConclusionThese findings motivate future studies to further explore multimodal physiotherapy interventions to improve balance in HD.
